Allergic reaction to Croscarmellose sodium used as excipient of a generic drug.

Croscarmellose sodium is a very commonly used pharmaceutical additive approved by the US Food and Drug Administration. It is used in injectable preparations as a suspending agent to promote solubilization of compounds with poor water solubility; it is also present in tablets as binder, glidant and antiadherent, in bulk laxatives as active principle and as an additive in food products. Croscarmellose hypersensitivity is a rarely reported event. We describe a case of a woman who developed allergic reaction to Croscarmellose used as excipient of a generic drug (generic preparation of oral furosemide) during treatment for chronic heart failure.